Design a FRET fusion-protein gBlock
Design a codon sequence for the prescribed five-part fusion protein with exact spectral choices, linker ordering, binding functions, and synthesis constraints.
protein-assembly
Normalized profile
What this task asks for
Design a codon sequence for the prescribed five-part fusion protein with exact spectral choices, linker ordering, binding functions, and synthesis constraints. Order antibody binder, donor, DHFR, acceptor, then molecule binder. Use PDB proteins for molecule binder, donor, and acceptor and plasmid DHFR. Match donor emission 610nm and acceptor excitation 505nm from FPbase. Place 5–20 amino-acid GS linkers only between subproteins. Omit start, stop, and noninitial N-terminal methionines. Stay within 3,000 nt and 30–70% GC in every 50-nt window.
Intent
- data transformation
- configuration tuning
Work surfaces
- protein design
- DNA sequence
Technology
- FRET
- FPbase
- Protein Data Bank
- gBlock
- codon optimization
Expected artifacts
- /app/gblock.txt
What makes it difficult
- strict behavioral compatibility or exact-output validation
- quantitative performance, accuracy, or resource constraints
- native compilation and dependency integration
- cross-language or cross-format integration
Published evidence
Model × harness outcomes
Counts are tied to these exact configurations. Harnesses are not treated as equivalent across benchmarks.
- Models
- 13
- Configurations
- 20
- Trials
- 100
Showing 20 of 20 configurations
| Model | Harness | Effort | Result | Passes |
|---|---|---|---|---|
| claude-fable-5anthropic · 2026-06-07 | claude-code2.1.167 | xhigh | No passes | 0/5 |
| claude-fable-5anthropic · 2026-06-05 | terminus-22.0.0 | high | Mixed | 3/5 |
| claude-opus-4-7anthropic · 2026-05-01 | claude-code2.1.123 | max | Mixed | 3/5 |
| claude-opus-4-7anthropic · 2026-05-01 | terminus-22.0.0 | max | Mixed2 errors | 3/5 |
| claude-opus-4-8anthropic · 2026-07-09 | claude-code2.1.205 | high | No passes1 errors | 0/5 |
| claude-sonnet-5anthropic · 2026-07-09 | claude-code2.1.205 | high | No passes5 errors | 0/5 |
| gemini-3-pro-previewgemini · 2026-05-01 | gemini-cli0.40.0 | high | No passes | 0/5 |
| gemini-3-pro-previewgemini · 2026-05-01 | terminus-22.0.0 | high | No passes | 0/5 |
| gemini-3.1-pro-previewgemini · 2026-05-05 | gemini-cli0.40.0 | high | Mixed | 1/5 |
| gemini-3.1-pro-previewgemini · 2026-05-05 | terminus-22.0.0 | high | No passes | 0/5 |
| glm-5.1zai · 2026-05-01 | claude-code2.1.123 | max | Mixed3 errors | 1/5 |
| gpt-5.5openai · 2026-05-01 | codex0.125.0 | xhigh | Mixed | 2/5 |
| gpt-5.5openai · 2026-05-01 | terminus-22.0.0 | xhigh | No passes | 0/5 |
| gpt-5.6-lunaopenai · 2026-07-10 | codex0.144.0 | max | Mixed | 1/5 |
| gpt-5.6-lunaopenai · 2026-07-11 | codex0.144.1 | max | Mixed | 3/5 |
| gpt-5.6-solopenai · 2026-07-10 | codex0.144.0 | max | Mixed1 disqualified | 2/5 |
| gpt-5.6-terraopenai · 2026-07-10 | codex0.144.0 | max | Mixed | 4/5 |
| gpt-5.6-terraopenai · 2026-07-11 | codex0.144.1 | max | Mixed | 4/5 |
| grok-4.5cursor · 2026-07-09 | cursor-cli2026.07.08-0c04a8a | default | Mixed2 disqualified | 1/5 |
| muse-spark-1.1openai · 2026-07-09 | mini-swe-agent2.4.5 | xhigh | Mixed | 2/5 |