Terminal-Bench 2.1terminalFASTADNA
Design Q5 mutagenesis primers
Design the minimum primer set that converts the circular input plasmid to the target sequence using the Q5 site-directed mutagenesis kit.
dna-insert
Normalized profile
What this task asks for
Design the minimum primer set that converts the circular input plasmid to the target sequence using the Q5 site-directed mutagenesis kit. Use 15–45 nucleotide input-annealing segments. Keep annealing Tm at 58–72°C and paired values within 5°C using the specified oligotm flags. Emit the minimum number of primer pairs. List each forward primer before its reverse partner.
Intent
- data transformation
- configuration tuning
Work surfaces
- primer design
- plasmid sequence
Technology
- PCR
- Q5 site-directed mutagenesis
- primer3
Expected artifacts
- primers.fasta
What makes it difficult
- quantitative performance, accuracy, or resource constraints
- cross-language or cross-format integration
Published evidence
Model × harness outcomes
Counts are tied to these exact configurations. Harnesses are not treated as equivalent across benchmarks.
- Models
- 13
- Configurations
- 20
- Trials
- 100
Showing 20 of 20 configurations
| Model | Harness | Effort | Result | Passes |
|---|---|---|---|---|
| claude-fable-5anthropic · 2026-06-07 | claude-code2.1.167 | xhigh | No passes | 0/5 |
| claude-fable-5anthropic · 2026-06-05 | terminus-22.0.0 | high | No passes | 0/5 |
| claude-opus-4-7anthropic · 2026-05-01 | claude-code2.1.123 | max | Mixed | 1/5 |
| claude-opus-4-7anthropic · 2026-05-01 | terminus-22.0.0 | max | Mixed | 2/5 |
| claude-opus-4-8anthropic · 2026-07-09 | claude-code2.1.205 | high | Mixed | 1/5 |
| claude-sonnet-5anthropic · 2026-07-09 | claude-code2.1.205 | high | No passes1 errors | 0/5 |
| gemini-3-pro-previewgemini · 2026-05-01 | gemini-cli0.40.0 | high | No passes | 0/5 |
| gemini-3-pro-previewgemini · 2026-05-01 | terminus-22.0.0 | high | Mixed | 1/5 |
| gemini-3.1-pro-previewgemini · 2026-05-05 | gemini-cli0.40.0 | high | No passes1 errors | 0/5 |
| gemini-3.1-pro-previewgemini · 2026-05-05 | terminus-22.0.0 | high | No passes1 errors | 0/5 |
| glm-5.1zai · 2026-05-01 | claude-code2.1.123 | max | No passes | 0/5 |
| gpt-5.5openai · 2026-05-01 | codex0.125.0 | xhigh | No passes | 0/5 |
| gpt-5.5openai · 2026-05-01 | terminus-22.0.0 | xhigh | Mixed | 1/5 |
| gpt-5.6-lunaopenai · 2026-07-10 | codex0.144.0 | max | No passes1 errors · 1 disqualified | 0/5 |
| gpt-5.6-lunaopenai · 2026-07-11 | codex0.144.1 | max | No passes | 0/5 |
| gpt-5.6-solopenai · 2026-07-10 | codex0.144.0 | max | Mixed | 2/5 |
| gpt-5.6-terraopenai · 2026-07-10 | codex0.144.0 | max | No passes | 0/5 |
| gpt-5.6-terraopenai · 2026-07-11 | codex0.144.1 | max | No passes | 0/5 |
| grok-4.5cursor · 2026-07-09 | cursor-cli2026.07.08-0c04a8a | default | Mixed | 3/5 |
| muse-spark-1.1openai · 2026-07-09 | mini-swe-agent2.4.5 | xhigh | Mixed | 2/5 |